Interesting read. I've owned many many bikes over the years and in my late 20s I switched from race reps to muscle bikes due to the pain I had in my wrists (doesn't help being over 6ft).
Since the swap I've never had an issue when riding sit up and beg bikes.
Then I built a couple of streetfighters and some choppers, owned a few big cc KTM supermotos and again absolutely no issues with wrist pain, lack of circulation etc until the Z1000sx.
So, as previously stated, I've ordered the top yoke conversion, I'll fit that once it arrives from Germany and I'm hoping that it will sort out the issue? If not, the bike will get put back to standard and sold.